Dysregulation of the Type 2 immune response5,7
Leads to increased signalling and production of IL-4 and IL-135
Which drives and perpetuates Type 2 inflammation5
Resulting in the clinical disease features of AD:4,6
AD, atopic dermatitis; IL, interleukin; IL-4Rα, interleukin 4 receptor alpha; ILC, innate lymphoid cells; Th, T-helper cells.