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Atopic dermatitis (AD) is a chronic disease driven by persistent underlying inflammation even in nonlesional or normal looking skin2–4

  • An imbalanced immune system, together with epidermal abnormalities, drive Type 2 inflammation2–4
  • IL-4 and IL-13 are key Th2 cytokines involved in AD2,4
  • These cytokines modulate the immune response, drive persistent inflammation and contribute to worsening barrier dysfunction2–4

Learn more about the pathophysiology of AD


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Not an actual patient.

Moderate-to-severe AD has a major impact on patients’ quality of life7

It’s important to understand the effect that AD has on patients’ lives.

EXPLORE PATIENT BURDEN

AD, atopic dermatitis; IL, interleukin; Th, T-helper cells.

References

  1. DUPIXENT Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/8553/smpc. Date accessed: December 2020.
  2. Leung DYM, et al. J Clin Invest. 2004;113(5):651–657.
  3. Suárez-Fariñas M, et al. J Allergy Clin Immunol. 2011;127(4):954–964.
  4. Gittler JK, et al. J Allergy Clin Immunol. 2012;130(6):1344–1354.
  5. Gandhi NA, et al. Nat Rev Drug Discov. 2016;15:35–50.
  6. Murota H & Katazyama I. Allergol Int. 2017;66:8–13.
  7. Simpson EL, et al. J Am Acad Dermatol. 2016;74(3):491–498.