DUPIXENT specifically targets the IL-4α receptor in severe asthma1–3


The interleukins; IL-4 and IL-13, are important in the development of Type 2 inflammation and its downstream effects in severe asthma2–7

DUPIXENT is a fully human monoclonal antibody for administration by subcutaneous injecton1

Learn more about how DUPIXENT works

DUPIXENT inhibits IL-4 and IL-13 signalling1,2


DUPIXENT:

Binds specifically to the IL-4Rα subunit shared by the receptor complexes for IL-4 and IL-131–4

Selectively inhibits the signalling of IL-4 via the Type 1 and 2 receptors for IL-41–4

Selectively inhibits IL-13 signalling via the Type 2 receptor for IL-131–4

Inhibition of IL-4 and IL-13 markedly decreases:1,2

Total and
allergen-specific IgE

Eosinophilic
lung inflammation

Fractional exhaled nitric oxide (FeNO), a marker
of IL-13 related to lung inflammation

INTRODUCING THE DUPIXENT PRE-FILLED PEN


DUPIXENT can be administered via
a pre-filled pen or a syringe1

Dupixent packs


Mode of disease


Learn more about the triggers of severe asthma.



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Safety profile


Learn more about the safety profile of DUPIXENT.
 


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Complexity of Type 2 inflammation

Learn more about the biomarkers involved in Type 2 inflammation.


Find out more

    FeNO, fractional exhaled nitric oxide; IgE, Immunoglobulin E; IL, interleukin; R, receptor; γC, gamma C subunit.

    References

    1. Sanofi Genzyme. Dupixent Summary of Product Characteristics, September 2021.
    2. Gandhi NA, et al. Nat Rev Drug Discov. 2016;15:35–50.
    3. Krings JG, et al. J Allergy Clin Immunol Pract. 2019;7(5):1379–1392.
    4. Doran E, et al. Front Med. 2017;4:139.
    5. Tran TN, et al. Ann Allergy Asthma Immunol. 2016;116(1):37–42.
    6. Seys SF, et al. Respir Res. 2017;18:39.
    7. Peters MC, et al. J Allergy Clin Immunol. 2014;133(2):388–394.

MAT-GB-2004974(v4.0) | Date of preparation: February 2022