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More than 181,000 patients have been prescribed DUPIXENT in North America and Europe as of November 2020, across indications1

  • DUPIXENT can be self-injected or administrated by a caregiver via a pre-filled pen or pre-filled syringe after appropriate training by a healthcare professional (HCP)2

200 mg for severe asthma patients excluding oral corticosteroid (OCS)-dependent patients2

Dosage Guide 200 mg

300 mg for OCS-dependent severe asthma patients and patients requiring DUPIXENT to control comorbid moderate-to-severe atopic dermatitis (AD) or severe Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)2

Dosage Guide 300 mg

Introducing the DUPIXENT pre-filled pen

A convenient option to ensure patients
administer DUPIXENT as directed2

Dupixent Pre-filled Pens 300 mg and 200 mg

DUPIXENT can be administered with a pre-filled pen or pre-filled syringe2

Learn how to administer DUPIXENT using the pre-filled pen or pre-filled syringe2

Getting to know the DUPIXENT pre-filled pen

1. Choose an injection site2,3

After removal from the refrigerator, lay the pre-filled pen on a flat surface and let it naturally warm up at room temperature (less than 25°C).

Wait 30 mins for the 200 mg pre-filled pen OR wait 45 mins for the 300 mg pre-filled pen.

 

Recommended injection sites are:

  • Thighs
  • Stomach
    Except the 5 cm around the belly button (navel).
  • Upper arms
    These areas are only for injections administered by a HCP or a caregiver.
  • Choose a different injection site for each DUPIXENT injection
  • Do not inject through clothes
  • Do not inject into skin that is tender, damaged, bruised or scarred

2. Prepare the injection site3

Wash your hands

Prepare the site by:

  • Cleaning the injection site with an alcohol wipe
  • Letting the skin dry before injection
  • Do not touch the injection site again or blow on it before the injection

3. Pull the cap off3

When you are ready, pull the cap straight off.

  • Do not twist the cap off
  • Do not remove the cap until you are ready to inject
  • Do not put the cap back on the pre-filled pen after you have removed it

4. Place the needle cover on the skin3

Place the needle cover on the skin, remember to:

  • Hold the pre-filled pen so that you can see the window
  • Place on the skin at approximately a 90° angle
  • Do not press or touch the needle cover with your fingers, the needle is inside

5. Press down3

Press the pre-filled pen firmly against the skin until you cannot see the needle cover, and hold:

  • There will be a “click” when the injection starts
  • The viewing window will start to turn yellow
  • The injection can take up to 20 seconds

6. Hold firmly3

Keep holding the pre-filled pen firmly against the skin:

  • You may hear a second click
  • Check that the entire viewing window has turned to yellow
  • Slowly count to 5
  • If the viewing window does not turn completely yellow, remove the pre-filled pen
  • Do not give a second dose, until you have investigated further

7. Removal and disposal2,3

After the injection is fully administered:

  • Remove the pre-filled pen from the skin
  • Dispose of the pre-filled pen, (needle inside), and cap in a puncture resistant container right away after use

If you see any blood at the injection site, lightly dab a cotton ball or gauze pad.

Disposal of the pre-filled pen illustration

  • Do not rub your skin after the injection
  • Do not put the cap back on
  • Advise patients not to throw away the pre-filled pen in household waste

It’s important to remember:2,3

  • Do not use the pre-filled pen if the expiration date has passed
  • Do not keep DUPIXENT at room temperature for more than 14 days
  • Do not use the pre-filled pen if the liquid is discoloured or cloudy, or if it contains visible flakes or particles
  • Do not use the pre-filled pen if the viewing window is yellow
  • Do not warm the pre-filled pen in a microwave, hot water, or direct sunlight
  • Do not use the pre-filled pen if it has been damaged
  • Do not use the pre-filled pen if the green cap is missing or not securely attached
  • Do not press or touch the needle cover with your fingers
  • Do not re-use the pre-filled pen

Getting to know the DUPIXENT pre-filled syringe

1. Choose an injection site2,4

After removal from the refrigerator, lay the pre-filled syringe on a flat surface and let it naturally warm up at room temperature (less than 25°C).

Wait 45 mins for the 300 mg pre-filled syringe.

 

Recommended injection sites are:

  • Thighs
  • Stomach
    Except the 5 cm around the belly button (navel).
  • Upper arms
    These areas are only for injections administered by a HCP or a caregiver.
  • Choose a different injection site for each DUPIXENT injection
  • Do not inject through clothes
  • Do not inject into skin that is tender, damaged, bruised or scarred

2. Prepare the injection site4

Wash your hands

Prepare the site by:

  • Cleaning the injection site with an alcohol wipe
  • Letting the skin dry before injection
  • Do not touch the injection site again or blow on it before the injection

3. Pull the cap off4

Hold the pre-filled syringe in the middle of the syringe body with the needle pointing away from you and pull off the needle cap.

  • Do not put the cap back on the pre-filled syringe after you have removed it
  • Do not touch the needle point
  • Inject your medicine immediately after removing the needle cap

4. Insert the needle into the skin4

Place the needle cover on the skin, remember to:

  • Using your thumb and index finger, pinch a fold of skin at the injection site
  • Insert the needle completely into the fold of skin at roughly a 45° angle
  • Do not touch the needle point

5. Press down4

  • Relax the pinch
  • Slowly and steadily push the plunger rod down as far as it will go until the pre-filled syringe is empty
  • You will feel some resistance, this is normal

6. Release and remove4

  • Lift your thumb to release the plunger rod until the needle is covered by the needle shield, then remove the pre-filled syringe from the injection site
  • Lightly press a cotton ball or gauze on the injection site if you see any blood
  • Do not put the needle cap back on
  • Do not rub your skin after the injection

7. Disposal2,4

Dispose of the pre-filled syringe and the needle cap in a puncture resistant container right away after use.

Disposal of the pre-filled syringe and the needle cap illustration

  • Always keep the container out of the reach of children

It’s important to remember:2,4

  • Do not use the pre-filled syringe if the expiration date has passed
  • Do not keep DUPIXENT at room temperature for more than 14 days
  • Do not use the pre-filled syringe if the liquid is discoloured or cloudy, or if it contains visible flakes or particles
  • Do not warm the pre-filled syringe in a microwave, hot water, or direct sunlight
  • Do not use the pre-filled syringe if it has been damaged
  • Do not use the pre-filled syringe if the cap is missing or not securely attached
  • Do not touch the needle
  • Do not re-use the pre-filled syringe

How to store DUPIXENT2

  • Keep the pre-filled pen(s) or pre-filled syringe(s) and all medicines out of the reach of children
  • Keep unused pre-filled pens or pre-filled syringes in the original carton and store in the refrigerator between 2°C and 8°C
  • Store pre-filled pens or pre-filled syringes in the original carton to protect it from light
  • Do not keep pre-filled pens or pre-filled syringes at room temperature (<25ºC) for more than 14 days2
  • Do not shake the pre-filled pen or pre-filled syringe at any time2
  • Do not heat the pre-filled pen or pre-filled syringe2
  • Do not freeze the pre-filled pen or pre-filled syringe2
  • Do not place the pre-filled pen or pre-filled syringe into direct sunlight2

AD, atopic dermatitis; CRSwNP, Chronic Rhinosinusitis with Nasal Polyposis; HCP, healthcare professional; OCS, oral corticosteroids.

References

  1. Sanofi Data on File. MAT-IE-2000837(v2.0). November 2020.
  2. Sanofi Genzyme. Dupixent Summary of Product Characteristics, May 2021.
  3. Dupixent Patient Information Leaflet for pre-filled pen. Available at: https://www.medicines.org.uk/emc/product/11321/pil. Date accessed: July 2021.
  4. Dupixent Patient Information Leaflet for pre-filled syringe. Available at: https://www.medicines.org.uk/emc/product/8553/pil. Date accessed: July 2021.