DUPIXENT is indicated in adults and adolescents 12 years and older as add-on maintenance treatment for severe asthma with Type 2 inflammation characterised by:1
raised blood eosinophils (EOS)
and/or raised fraction of exhaled nitric oxide (FeNO)
who are inadequately controlled with high-dose inhaled corticosteroids (ICS) plus another medicinal product for maintenance treatment
Over 48,000 patients aged 12 years or older have been prescribed DUPIXENT for moderate-to-severe asthma in North America and Europe as of July 20211
More than 320,000 patients have been prescribed DUPIXENT in North America and Europe as of July 2021, across indications1
DUPIXENT can be self-injected or administrated by a caregiver via a pre-filled pen or pre-filled syringe after appropriate training by a healthcare professional (HCP)2
200 mg for severe asthma patients excluding oral corticosteroid
(OCS)-dependent patients2
300 mg for OCS-dependent severe asthma patients and patients requiring DUPIXENT to control comorbid moderate-to-severe atopic dermatitis (AD) or severe Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)2
Introducing the DUPIXENT pre-filled pen
DUPIXENT pre-filled pen can be used to ensure
patients administer DUPIXENT as directed2
DUPIXENT can be administered with a pre-filled pen or pre-filled syringe2
Learn how to administer DUPIXENT using the pre-filled pen or pre-filled syringe2
-
1. Choose an injection site2,4
After removal from the refrigerator, lay the pre-filled pen on a flat surface and let it naturally warm up at room temperature (less than 25°C).
Wait 45 mins for the 300 mg pre-filled syringe.Recommended injection sites are:
> Thighs
> Stomach
Except the 5 cm around the belly button (navel).
> Upper arms
These areas are only for injections administered by a HCP or a
caregiver.
> Choose a different injection site for each DUPIXENT injection
> Do not inject through clothes
> Do not inject into skin that is tender, damaged, bruised or scarred2. Prepare the injection site4
Wash your hands
Prepare the site by:
> Cleaning the injection site with an alcohol wipe
> Letting the skin dry before injection
> Do not touch the injection site again or blow on it before the injection
3. Pull the cap off4
Hold the pre-filled syringe in the middle of the syringe body with the needle pointing away from you and pull off the needle cap.
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> Do not put the cap back on the pre-filled syringe after you have removed it
> Do not touch the needle point
> Inject your medicine immediately after removing the needle cap4. Insert the needle into the skin4
Place the needle cover on the skin, remember to:
> Using your thumb and index finger, pinch a fold of skin at the
injection site
> Insert the needle completely into the fold of skin at roughly a 45°
angle
> Do not touch the needle point
5. Press down4
> Relax the pinch
> Slowly and steadily push the plunger rod down as far as it will go
until the pre-filled syringe is empty
> You will feel some resistance, this is normal
6. Release and remove4
> Lift your thumb to release the plunger rod
until the needle is covered by the needle
shield, then remove the pre-filled syringe
from the injection site> Lightly press a cotton ball or gauze on the
injection site if you see any blood
> Do not put the needle cap back on
> Do not rub your skin after the injection7. Disposal2,4
Dispose of the pre-filled syringe and the needle cap in a puncture resistant container right away after use.
Always keep the container out of the reach of children
-
1. Choose an injection site2,3
After removal from the refrigerator, lay the pre-filled pen on a flat surface and let it naturally warm up at room temperature (less than 25°C).
Wait 30 mins for the 200 mg pre-filled pen OR wait 45 mins for the 300 mg pre-filled pen.
Recommended injection sites are:
> Thighs
> Stomach
Except the 5 cm around the belly button (navel).
> Upper arms
These areas are only for injections administered by a HCP or a
caregiver.> Choose a different injection site for each DUPIXENT injection
> Do not inject through clothes
> Do not inject into skin that is tender, damaged, bruised or scarred2. Prepare the injection site3
Wash your hands
Prepare the site by:
> Cleaning the injection site with an alcohol wipe
> Letting the skin dry before injection> Do not touch the injection site again or blow on it before the injection
3. Pull the cap off3
When you are ready, pull the cap straight off.
> Do not twist the cap off
> Do not remove the cap until you are ready to inject
> Do not put the cap back on the pre-filled pen after you have removed it4. Place the needle cover on the skin3
Place the needle cover on the skin, remember to:
> Hold the pre-filled pen so that you can see the window
> Place on the skin at approximately a 90° angle
> Do not press or touch the needle cover with your fingers, the needle is inside
5. Press down3
Press the pre-filled pen firmly against the skin until you cannot see the needle cover, and hold:
> There will be a “click” when the injection starts
> The viewing window will start to turn yellow
> The injection can take up to 20 seconds
6. Hold firmly3
Keep holding the pre-filled pen firmly against the skin:
> You may hear a second click
> Check that the entire viewing window has turned to yellow
> Slowly count to 5
> If the viewing window does not turn completely yellow, remove the pre-filled pen
> Do not give a second dose, until you have investigated further
7. Removal and disposal2,3
After the injection is fully administered:
> Remove the pre-filled pen from the skin
> Dispose of the pre-filled pen, (needle inside), and cap in a puncture
resistant container right away after useIf you see any blood at the injection site, lightly dab a cotton ball or gauze pad.
> Do not rub your skin after the injection
> Do not put the cap back on
> Advise patients not to throw away the pre-filled pen in household waste
How to store DUPIXENT2
Keep the pre-filled pen(s) or pre-filled syringe(s) and all medicines out of the reach of children
Keep unused pre-filled pens or pre-filled syringes in the original carton and store in the refrigerator between 2°C and 8°C
Store pre-filled pens or pre-filled syringes in the original carton to protect it from light
Do not keep pre-filled pens or pre-filled syringes at room temperature (<25ºC) for more than 14 days2
Do not freeze the pre-filled pen or pre-filled syringe2
Do not shake the pre-filled pen or pre-filled syringe at any time2
Do not place the pre-filled pen or pre-filled syringe into direct sunlight2
Do not heat the pre-filled pen or pre-filled syringe2
Exacerbations and lung function
DUPIXENT can improve exacerbations and lung function of 12+ years old patients with severe asthma
- Sanofi Data on File. MAT-IE-2000837(v2.0). July 2021.
- Sanofi Genzyme. Dupixent Summary of Product Characteristics, June 2022.
- Dupixent Patient Information Leaflet for pre-filled pen. Available at: https://www.medicines.org.uk/emc/product/11321/pil. Date accessed: June 2022.
- Dupixent Patient Information Leaflet for pre-filled syringe. Available at: https://www.medicines.org.uk/emc/product/8553/pil. Date accessed: June 2022.
AD, atopic dermatitis; CRSwNP, Chronic Rhinosinusitis with Nasal Polyposis; HCP, healthcare professional; OCS, oral corticosteroids.
References
MAT-GB-2004975(v7.0) | Date of preparation: June 2022
