FOR UK HEALTHCARE PROFESSIONALS ONLY
For UK Healthcare Professionals Only

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More than 181,000 patients have been prescribed DUPIXENT in North America and Europe as of November 2020, across indications1

  • DUPIXENT can be self-injected or administrated by a caregiver via a pre-filled pen or pre-filled syringe after appropriate training by a healthcare professional (HCP)2

200 mg for severe asthma patients excluding oral corticosteroid (OCS)-dependent patients2

Dosage Guide 200 mg

300 mg for OCS-dependent severe asthma patients and patients requiring DUPIXENT to control comorbid moderate-to-severe atopic dermatitis (AD) or severe Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)2

Dosage Guide 300 mg

Introducing the DUPIXENT pre-filled pen

A convenient option to ensure patients
administer DUPIXENT as directed2

Dupixent Pre-filled Pens 300 mg and 200 mg

DUPIXENT can be administered with a pre-filled pen or pre-filled syringe2

Learn how to administer DUPIXENT using the pre-filled pen or pre-filled syringe2

Getting to know the DUPIXENT pre-filled pen

1. Choose an injection site2,3

After removal from the refrigerator, lay the pre-filled pen on a flat surface and let it naturally warm up at room temperature (less than 25°C).

Wait 30 mins for the 200 mg pre-filled pen OR wait 45 mins for the 300 mg pre-filled pen.

 

Recommended injection sites are:

  • Thighs
  • Stomach
    Except the 5 cm around the belly button (navel).
  • Upper arms
    These areas are only for injections administered by a HCP or a caregiver.
  • Choose a different injection site for each DUPIXENT injection
  • Do not inject through clothes
  • Do not inject into skin that is tender, damaged, bruised or scarred

2. Prepare the injection site3

Wash your hands

Prepare the site by:

  • Cleaning the injection site with an alcohol wipe
  • Letting the skin dry before injection
  • Do not touch the injection site again or blow on it before the injection

3. Pull the cap off3

When you are ready, pull the cap straight off.

  • Do not twist the cap off
  • Do not remove the cap until you are ready to inject
  • Do not put the cap back on the pre-filled pen after you have removed it

4. Place the needle cover on the skin3

Place the needle cover on the skin, remember to:

  • Hold the pre-filled pen so that you can see the window
  • Place on the skin at approximately a 90° angle
  • Do not press or touch the needle cover with your fingers, the needle is inside

5. Press down3

Press the pre-filled pen firmly against the skin until you cannot see the needle cover, and hold:

  • There will be a “click” when the injection starts
  • The viewing window will start to turn yellow
  • The injection can take up to 20 seconds

6. Hold firmly3

Keep holding the pre-filled pen firmly against the skin:

  • You may hear a second click
  • Check that the entire viewing window has turned to yellow
  • Slowly count to 5
  • If the viewing window does not turn completely yellow, remove the pre-filled pen
  • Do not give a second dose, until you have investigated further

7. Removal and disposal2,3

After the injection is fully administered:

  • Remove the pre-filled pen from the skin
  • Dispose of the pre-filled pen, (needle inside), and cap in a puncture resistant container right away after use

If you see any blood at the injection site, lightly dab a cotton ball or gauze pad.

Disposal of the pre-filled pen illustration

  • Do not rub your skin after the injection
  • Do not put the cap back on
  • Advise patients not to throw away the pre-filled pen in household waste

It’s important to remember:2,3

  • Do not use the pre-filled pen if the expiration date has passed
  • Do not keep DUPIXENT at room temperature for more than 14 days
  • Do not use the pre-filled pen if the liquid is discoloured or cloudy, or if it contains visible flakes or particles
  • Do not use the pre-filled pen if the viewing window is yellow
  • Do not warm the pre-filled pen in a microwave, hot water, or direct sunlight
  • Do not use the pre-filled pen if it has been damaged
  • Do not use the pre-filled pen if the green cap is missing or not securely attached
  • Do not press or touch the needle cover with your fingers
  • Do not re-use the pre-filled pen

Getting to know the DUPIXENT pre-filled syringe

1. Choose an injection site2,4

After removal from the refrigerator, lay the pre-filled syringe on a flat surface and let it naturally warm up at room temperature (less than 25°C).

Wait 45 mins for the 300 mg pre-filled syringe.

 

Recommended injection sites are:

  • Thighs
  • Stomach
    Except the 5 cm around the belly button (navel).
  • Upper arms
    These areas are only for injections administered by a HCP or a caregiver.
  • Choose a different injection site for each DUPIXENT injection
  • Do not inject through clothes
  • Do not inject into skin that is tender, damaged, bruised or scarred

2. Prepare the injection site4

Wash your hands

Prepare the site by:

  • Cleaning the injection site with an alcohol wipe
  • Letting the skin dry before injection
  • Do not touch the injection site again or blow on it before the injection

3. Pull the cap off4

Hold the pre-filled syringe in the middle of the syringe body with the needle pointing away from you and pull off the needle cap.

  • Do not put the cap back on the pre-filled syringe after you have removed it
  • Do not touch the needle point
  • Inject your medicine immediately after removing the needle cap

4. Insert the needle into the skin4

Place the needle cover on the skin, remember to:

  • Using your thumb and index finger, pinch a fold of skin at the injection site
  • Insert the needle completely into the fold of skin at roughly a 45° angle
  • Do not touch the needle point

5. Press down4

  • Relax the pinch
  • Slowly and steadily push the plunger rod down as far as it will go until the pre-filled syringe is empty
  • You will feel some resistance, this is normal

6. Release and remove4

  • Lift your thumb to release the plunger rod until the needle is covered by the needle shield, then remove the pre-filled syringe from the injection site
  • Lightly press a cotton ball or gauze on the injection site if you see any blood
  • Do not put the needle cap back on
  • Do not rub your skin after the injection

7. Disposal2,4

Dispose of the pre-filled syringe and the needle cap in a puncture resistant container right away after use.

Disposal of the pre-filled syringe and the needle cap illustration

  • Always keep the container out of the reach of children

It’s important to remember:2,4

  • Do not use the pre-filled syringe if the expiration date has passed
  • Do not keep DUPIXENT at room temperature for more than 14 days
  • Do not use the pre-filled syringe if the liquid is discoloured or cloudy, or if it contains visible flakes or particles
  • Do not warm the pre-filled syringe in a microwave, hot water, or direct sunlight
  • Do not use the pre-filled syringe if it has been damaged
  • Do not use the pre-filled syringe if the cap is missing or not securely attached
  • Do not touch the needle
  • Do not re-use the pre-filled syringe

How to store DUPIXENT2

  • Keep the pre-filled pen(s) or pre-filled syringe(s) and all medicines out of the reach of children
  • Keep unused pre-filled pens or pre-filled syringes in the original carton and store in the refrigerator between 2°C and 8°C
  • Store pre-filled pens or pre-filled syringes in the original carton to protect it from light
  • Do not keep pre-filled pens or pre-filled syringes at room temperature (<25ºC) for more than 14 days2
  • Do not shake the pre-filled pen or pre-filled syringe at any time2
  • Do not heat the pre-filled pen or pre-filled syringe2
  • Do not freeze the pre-filled pen or pre-filled syringe2
  • Do not place the pre-filled pen or pre-filled syringe into direct sunlight2

Mode of action
DUPIXENT

Have questions about how DUPIXENT works?

Find out more

Exacerbations, lung function and QoL

Learn more about how DUPIXENT can improve the QoL of adult and adolescents patients with severe asthma.

Find out more

Safety profile

Learn more about the safety profile of DUPIXENT.

Find out more

AD, atopic dermatitis; CRSwNP, Chronic Rhinosinusitis with Nasal Polyposis; HCP, healthcare professional; OCS, oral corticosteroids.

References

  1. Sanofi Data on File. MAT-IE-2000837(v2.0). November 2020.
  2. Sanofi Genzyme. Dupixent Summary of Product Characteristics, May 2021.
  3. Dupixent Patient Information Leaflet for pre-filled pen. Available at: https://www.medicines.org.uk/emc/product/11321/pil. Date accessed: July 2021.
  4. Dupixent Patient Information Leaflet for pre-filled syringe. Available at: https://www.medicines.org.uk/emc/product/8553/pil. Date accessed: July 2021.