IL-4 and IL-13 are key drivers of Type 2 inflammation in severe asthma1–4
Type 2 cytokines drive the recruitment of effector cells (e.g. eosinophils) and mediate class switching of B cells to secrete IgE upon exposure to antigens5
Hallmarks of Type 2 pathway activation include IgE production and eosinophilia6
The Type 2 cytokine IL-4 drives the differentiation and clonal expansion of Th cells6
IL-4 and IL-13 are primarily responsible for isotype class switching of B cells to produce IgE6
IL-13 effects include mucus secretion, smooth muscle contractility and hyperplasia6
Adapted from Robinson D et al. 2017,5 Gandhi NA et al. 2016,6 Krings JG et al. 2019,7 Lambrecht BN and Hammad H 2015,8 Fahy J. 2015,9 and Le Floc’h A et al. 2020.10
- Tran TN, et al. Ann Allergy Asthma Immunol. 2016;116(1):37–42.
- Seys SF, et al. Respir Res. 2017;18:39.
- Peters MC, et al. J Allergy Clin Immunol. 2014;133(2):388–394.
- Doran E, et al. Front Med. 2017;4:139.
- Robinson D, et al. Clin Exp Allergy. 2017;47(2):161–175.
- Gandhi NA, et al. Nat Rev Drug Discov. 2016;15:35–50.
- Krings JG, et al. J Allergy Clin Immunol Pract. 2019;7(5):1379–1392.
- Lambrecht BN and Hammad H. Nat Immunol. 2015;16(1):45–46.
- Fahy JV. Nat Rev Immunol. 2015;15(1):57–65.
- Le Floc’h A, et al. Allergy. 2020;75(5):1188–1204.
IgE, Immunoglobulin E; IL, interleukin; ILC, innate lymphoid cells; PGD2, Prostaglandin D2; Th, T-helper.
References
MAT-GB-2004973 (v8.0) | Date of preparation: May 2023.