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Consider prescribing DUPIXENT for patients aged 12 years and older with moderate-to-severe AD and for children aged 6–11 years with severe AD

  • DUPIXENT may be prescribed to patients aged 12 years or older with moderate-to-severe AD and children aged 6–11 years old with severe AD, who are candidates for systemic therapy1
  • DUPIXENT may be an appropriate choice for patients who are struggling to control their disease1
  • DUPIXENT can be used with or without TCS1

MICHAEL

Chronic, long-term, persistent disease

  • 47 years old, diagnosed in early childhood
  • Moderate-to-severe AD
  • Lichenified lesions frequently infected
  • Persistent itch, sleep loss

EASI score: 25

Current treatment:
Methotrexate

DLQI: 15

Prior treatments:
Failed rounds of ciclosporin

MICHAEL

Impact

  • Repeated antibiotic use
  • Feels conscious of his appearance in public
  • Persistent severe itch
  • Frequent sleep loss affects work performance and family life

Clinical assessment:

Lacks long-term disease control with current treatment

MICHAEL

Treatment goals

  • Reduce itching
  • Heal skin lesions
  • Improve his quality of life, including sleep
  • Spend less time on therapies requiring a frequent follow-up and lab monitoring

Illustrative patient profiles, not actual patients.

SHANNON

Moderate disease, with flares

  • 26 years old, diagnosed in early childhood Moderate AD
  • Troublesome flares
  • Sore lesions and itch
  • Sleep disturbance

EASI score: 16

Current treatment:
Topical corticosteroids

DLQI: 20

Prior treatments:
Non-responder to ciclosporin

SHANNON

Impact

  • Painful lesions in flexural areas
  • Lack of sleep causing fatigue which impacts daily life, including social activities
  • Feels anxious from the lack of AD control
  • Frustrated with not being able to control her disease

Clinical assessment:

Inadequate clinical improvement with current treatment

SHANNON

Treatment goals

  • Reduce itching
  • Heal skin lesions
  • Find a long-term treatment that adequately controls her disease
  • Find a treatment that allows her to get on with everyday life

Illustrative patient profiles, not actual patients.

GEORGE

Chronic, long-term, persistent disease

  • 15 years old, diagnosed eight years ago
  • Moderate-to-severe AD
  • Intense lesions and itch

EASI score: 30

Current treatment:
Topical corticosteroids

DLQI: 20

Prior treatments:
Non-responder to ciclosporin

GEORGE

Impact

  • Highly visible lesions on face have an impact on social life
  • Itch distracts him during lessons and keeps him up at night
  • Eight prolonged school absences this year due to disease
  • Experiences bullying due to disease with serious implication for his mental health

Clinical assessment:

Inadequate clinical improvement with current treatment

GEORGE

Treatment goals

  • Reduce itching
  • Heal skin lesions
  • Become less distracted by his symptoms and get a good night’s rest
  • Reduce the number of days taken off school

Illustrative patient profiles, not actual patients.

MARIE

Severe AD

  • Seven years old, diagnosed at age one
  • Severe AD
  • Chronic lesions on face and across the body
  • Has not achieved control of her disease since diagnosis
  • Six secondary care consultations in the past year

EASI score: 30

Current treatment:
TCS & MTX

CDLQI: 20

Prior treatments:
Tacrolimus (TCI)

MARIE

Impact

  • Frequent worsening of disease results in sleeplessness and missed school days, causing her parents to miss work
  • Feels isolated from her classmates because of her severe AD and experiences anxiety
  • Parents are anxious about her future of living with the disease and the impact it will have later in life

Clinical assessment:

Inadequate clinical improvement with current treatment

MARIE

Treatment goals

  • Long-term reduction of itch and lesions
  • Be able to socialise more with her friends
  • Be able to focus on her school work rather than her AD symptoms
  • Find an efficacious treatment that is licensed for use in children

Illustrative patient profiles, not actual patients.

Patients like Michael, Shannon
George and Marie can benefit
from treatment with DUPIXENT

  • DUPIXENT provides improvements in lesion extent and severity, pruritus intensity and quality-of-life measure versus placebo1–7
  • DUPIXENT has investigated a safety profile in clinical studies in patients as young as 6 years old1

AD, atopic dermatitis; CDLQI, Children’s Dermatology Life Quality Index; DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; MTX, methotrexate; TCI, tacrolimus; TCS, topical corticosteroids.

References

  1. DUPIXENT Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/8553/smpc. Date accessed: July 2021.
  2. Blauvelt A, et al. Lancet. 2017;389:2287–2303.
  3. de Bruin-Weller M et al. Clinically Meaningful Responses in Moderate-to-Severe Atopic Dermatitis Patients Treated with Dupilumab (Presentation) presented at the 27th European Academy of Dermatology and Venereology Congress, Paris, France, September 12–16 2018.
  4. Simpson EL, et al. JAMA Dermatol. 2020;156(1):44–56.
  5. Paller AS, et al. Am J Clin Dermatol. 2020;21:119–131.
  6. Paller AS, et al. Dupilumab Significantly Improves Atopic Dermatitis in Children Aged ≥6 to <12 years: Results From Phase 3 Trial (LIBERTY AD PEDS) (Presentation) presented at the virtual Revolutionizing Atopic Dermatitis Conference, Chicago, IL, USA, April 5th 2020.
  7. Sanofi Data on File. MAT-GB-2005006 (v1.0).