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More than 239,200 patients aged 12 years or older with moderate-to-severe atopic dermatitis (AD) and children aged 6–11 years old with severe AD have been prescribed DUPIXENT worldwide as of July 20212

Children
15 to <60kg
Children
≥60kg
Adolescents
<60 kg
Adolescents & all adults
≥60 kg
Pre-filled syringe
Pre-filled pen
Self-administration
HCP/caregiver administered
Dosing frequency Q4W/Q2W Q2W Q2W Q2W
  • DUPIXENT can be self-injected or administrated by a caregiver/HCP via a pre-filled pen or syringe for adults and adolescent1
  • For children aged 6–11 years old, DUPIXENT can only be administered by a caregiver via a pre-filled syringe after appropriate training by a HCP1
  • There is weight-based dosing for adolescents (12 years and older) with moderate-to-severe AD and for children (6–11 years old) with severe AD1


*After the initial dose, the dosing may be increased to 200 mg Q2W in patients with body weight of 15 kg to less than 60 kg based on physician’s assessment.1

DUPIXENT can now be administered with a pre-filled pen for patients aged 12 years and older1

Learn how to administer DUPIXENT using the single-use, pre-filled pen.1

Getting to know the DUPIXENT pre-filled pen

  • The 300 mg solution pre-filled pen is green
  • The 200 mg solution pre-filled pen is yellow

Before DUPIXENT adminstration

Ensure you have the following:

  • The DUPIXENT pre-filled pen
  • 1 alcohol wipe
  • 1 cotton ball or gauze
  • A puncture-resistant container
  • 1

    Check the label
    Confirm you have the correct product and dose

  • 2

    Check expiration date

  • 3

    Check the medicine
    Look at the medicine through the viewing window and check to see if the liquid is a clear and colourless

1. Choose an injection site

After removal from the refrigerator, lay the pen on a flat surface and let it naturally warm up at room temperature (less than 25°C).

Wait 30 mins for the 200 mg pen OR wait 45 mins for the 300 mg pen.

Recommended injection sites are:

  • Thighs
  • Stomach
    Except the 5 cm around the belly button (navel).
  • Upper arms
    These areas are only for injections administered by a HCP or a caregiver.
  • Choose a different injection site for each DUPIXENT injection
  • Do not inject through clothes
  • Do not inject into skin that is tender, damaged, bruised or scarred

2. Prepare the injection site

Wash your hands

Prepare the site by:

  • Cleaning the injection site with an alcohol wipe
  • Letting the skin dry before injection
  • Do not touch the injection site again or blow on it before the injection

3. Pull the cap off

When you are ready, pull the cap straight off.

  • Do not twist the cap off
  • Do not remove the cap until you are ready to inject
  • Do not put the cap back on the pre-filled pen after you have removed it

4. Place the needle cover on the skin

Place the needle cover on the skin, remember to:

  • Hold the pen so that you can see the window
  • Place on the skin at approximately a 90° angle
  • Do not press or touch the needle cover with your fingers, the needle is inside

5. Press down

Press the pre-filled pen firmly against the skin until you cannot see the needle cover, and hold:

  • There will be a “click” when the injection starts
  • The viewing window will start to turn yellow
  • The injection can take up to 20 seconds

6. Hold firmly

Keep holding the pre-filled pen firmly against the skin:

  • You may hear a second click
  • Check that the entire viewing window has turned to yellow
  • Slowly count to 5
  • If the viewing window does not turn completely yellow, remove the pen
  • Do not give a second dose, until you have investigated further

7. Removal and disposal

After the injection is fully administered:

  • Remove the pre-filled pen from the skin
  • Dispose of the pre-filled pen, (needle inside), and cap in a puncture resistant container right away after use

If you see any blood at the injection site, lightly dab a cotton ball or gauze pad.

  • Do not rub the skin after injection
  • Do not put the cap back on
  • Advise patients not to throw away in household waste

It’s important to remember:

  • Do not use the pre-filled pen if the expiration date has passed
  • Do not keep DUPIXENT at room temperature for more than 14 days
  • Do not use the pre-filled pen if the liquid is discoloured or cloudy, or if it contains visible flakes or particles
  • Do not use the pre-filled pen if the viewing window is yellow
  • Do not warm the pre-filled pen in a microwave, hot water, or direct sunlight
  • Do not use the pre-filled pen if it has been damaged
  • Do not use the pre-filled pen if the green cap is missing or not securely attached
  • Do not press or touch the needle cover with your fingers
  • Do not re-use the pre-filled pen

How to store DUPIXENT1

  • Keep the pre-filled pen(s) or syringe(s) and all medicines out of the reach of children1
  • Keep unused pre-filled pens or syringes in the original carton and store in the refrigerator between 2°C and 8°C1
  • Store pre-filled pens or syringes in the original carton to protect it from light1
  • Do not keep pre-filled pens or syringes at room temperature (<25oC) for more than 14 days1
  • Do not shake the pre-filled pen or syringe at any time1
  • Do not heat the pre-filled pen or syringe1
  • Do not freeze the pre-filled pen or syringe1
  • Do not place the pre-filled pen or syringe into direct sunlight1

AD, atopic dermatitis; HCP, healthcare professional; Q2W, once every two weeks; Q4W, once every four weeks.

References

  1. DUPIXENT Summary of Product Characteristics. September 2021.
  2. Sanofi Data on File. MAT-IE-2000837 (v3.0).