Mechanism of disease

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For UK Healthcare Professionals Only

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The dysregulated Type 2 immune response drives AD

Three types of immune response play a natural protective role against different pathogens, the Type 2 immune response drives AD specifically^2-4

Type 2 inflammation, due to increased signalling of IL-4 and IL-13, contributes to the clinical disease features of AD^4–6

1

Dysregulation of the Type 2 immune response^5,7

2

Leads to increased signalling and production of IL-4 and IL-13⁵

3

Which drives and perpetuates Type 2 inflammation⁵

4

Resulting in the clinical disease features of AD:^4,6

Skin barrier dysfunction
Skin lesions

Itch
Increased susceptibility to skin infections

Selectively targeting a single signalling receptor, the IL-4Rα, thereby inhibiting IL-4 and IL-13 signalling, can help to reduce the persistent underlying Type 2 inflammation in AD⁸

Learn more about the pathophysiology of AD

Watch video

AD, atopic dermatitis; IL, interleukin; IL-4Rα, interleukin 4 receptor alpha; ILC, innate lymphoid cells; Th, T-helper cells.

References

DUPIXENT Summary of Product Characteristics. September 2021.
Leung DYM, et al. J Clin Invest. 2004;113(5):651–657.
Suárez-Fariñas M, et al. J Allergy Clin Immunol. 2011;127(4):954–964.
Gittler JK, et al. J Allergy Clin Immunol. 2012;130(6):1344–1354.
Gandhi NA, et al. Nat Rev Drug Discov. 2016;15:35–50.
Biedermann T, et al. Front Immunol. 2015;6:353.
Artis D & Spits H. Nature. 2015;517:293–301.
Guttman-Yassky E, et al. J Allergy Clin Immunol. 2019;143:155– 172.