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Management approaches in moderate-to-severe AD should address the persistent underlying Type 2 inflammation

  • Three types of immune response play a natural protective role against different pathogens, the Type 2 immune response drives AD specifically2–4
  • Broad spectrum immunosuppressants do not specifically inhibit Type 2 inflammatory pathway5–7
  • Non-specific mechanisms may result in unwanted side effects and the need for lab monitoring, limiting traditional systemic treatments as long-term therapeutic options2,5–10

IL-4 and IL-13 drive Type 2 inflammation

IL-4 and IL-13 are key Type 2 cytokines involved in the pathogenesis of AD2,4


DUPIXENT targets Type 2 inflammation

DUPIXENT inhibits IL-4 and IL-13 signalling, and reduces persistent underlying Type 2 inflammation in AD1,20


DUPIXENT demonstrated a safety profile in clinical studies that is consistent in adults, adolescents and children1

  • DUPIXENT has a long-term safety and tolerability profile that has been investigated up to 3 years in clinical trials in adults1,21
  • The long-term safety profile seen in adults is consistent with the safety profile of adolescents and children, seen at 16 weeks1,22,23
  • DUPIXENT does not require routine laboratory monitoring1

AD, atopic dermatitis; IFNγ, interferon gamma; IL, interleukin; ILC, innate lymphoid cells; JAK, Janus kinase; NK, natural killer cells; Th, T-helper cells; TNF, tumour necrosis factor.


  1. DUPIXENT Summary of Product Characteristics. September 2021.
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  21. Thaçi D, et al. Favorable Safety and Sustained Efficacy With Long-Term Dupilumab Treatment in Adults With Moderate-to-Severe Atopic Dermatitis: An Analysis up to 3 Years (LIBERTY AD OLE) presented at the 20th Annual Las Vegas Dermatology Seminar, Nevada, USA, November 7–9 2019.
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