Management approaches in moderate-to-severe AD should address the persistent underlying Type 2 inflammation
Three types of immune response play a natural protective role against different pathogens, the Type 2 immune response drives AD specifically2–4
Broad spectrum immunosuppressants do not specifically inhibit Type 2 inflammatory pathway5–7
Non-specific mechanisms may result in unwanted side effects and the need for lab monitoring, limiting traditional systemic treatments as long-term therapeutic options2,5–10
IL-4 and IL-13 drive Type 2 inflammation
IL-4 and IL-13 are key Type 2 cytokines involved in the pathogenesis of AD2,4


DUPIXENT targets Type 2 inflammation
DUPIXENT inhibits IL-4 and IL-13 signalling, and reduces persistent underlying Type 2 inflammation in AD1,20
DUPIXENT demonstrated a safety profile in clinical studies that is consistent in adults, adolescents and children1
DUPIXENT has a long-term safety and tolerability profile that has been investigated up to 3 years in clinical trials in adults1,21
The long-term safety profile seen in adults is consistent with the safety profile of adolescents and children, seen at 16 weeks1,22,23
DUPIXENT does not require routine laboratory monitoring1
- DUPIXENT Summary of Product Characteristics. September 2021.
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- Coates LC, et al. Semin Arthritis Rheum. 2016;46:291–304.
- Blauvelt A, et al. Lancet. 2017;389(10086):2287–2303.
- Thaçi D, et al. Favorable Safety and Sustained Efficacy With Long-Term Dupilumab Treatment in Adults With Moderate-to-Severe Atopic Dermatitis: An Analysis up to 3 Years (LIBERTY AD OLE) presented at the 20th Annual Las Vegas Dermatology Seminar, Nevada, USA, November 7–9 2019.
- Paller AS, et al. Am J Clin Derm. 2020;21(1): 119–131.
- Paller AS, et al. J Am Acad Dermatol. 2020;83(5):1282–1293.
AD, atopic dermatitis; IFNγ, interferon gamma; IL, interleukin; ILC, innate lymphoid cells; JAK, Janus kinase; NK, natural killer cells; Th, T-helper cells; TNF, tumour necrosis factor.
References
MAT-IE-2101040(v4.0) | Date of preparation: February 2022