Atopic dermatitis (AD) is a chronic disease driven by persistent underlying inflammation even in nonlesional or normal looking skin2–4
An imbalanced immune system, together with epidermal abnormalities, drive Type 2 inflammation2–4
IL-4 and IL-13 are key Th2 cytokines involved in AD2–4
These cytokines modulate the immune response, drive persistent inflammation and contribute to worsening barrier dysfunction2–4
Learn more about the pathophysiology of AD

Moderate-to-severe AD has a major impact on patients’ quality of life7
It’s important to understand the effect that AD has on patients’ lives.
Inflammatory pathways
What are the main inflammatory pathways involved in the disease? Find out about the pathway involved in AD.
Find out more
- DUPIXENT Summary of Product Characteristics. September 2021.
- Leung DYM, et al. J Clin Invest. 2004;113(5):651–657.
- Suárez-Fariñas M, et al. J Allergy Clin Immunol. 2011;127(4):954–964.
- Gittler JK, et al. J Allergy Clin Immunol. 2012;130(6):1344–1354.
- Gandhi NA, et al. Nat Rev Drug Discov. 2016;15:35–50.
- Artis D & Spits H. Nature. 2015;517:293–301.
- Biedermann T, et al. Front Immunol. 2015;6:353.
AD, atopic dermatitis; IL, interleukin; Th, T-helper cells.
References
MAT-IE-2101040(v4.0) | Date of preparation: February 2022