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Atopic dermatitis (AD) is a chronic disease driven by persistent underlying inflammation even in nonlesional or normal looking skin2–4

  • An imbalanced immune system, together with epidermal abnormalities, drive Type 2 inflammation2–4
  • IL-4 and IL-13 are key Th2 cytokines involved in AD2–4
  • These cytokines modulate the immune response, drive persistent inflammation and contribute to worsening barrier dysfunction2–4
UNDERLYING TYPE 2 INFLAMMATION

Learn more about the pathophysiology of AD


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Not an actual patient.

Moderate-to-severe AD has a major impact on patients’ quality of life7

It’s important to understand the effect that AD has on patients’ lives.

EXPLORE PATIENT BURDEN

Mode of action DUPIXENT

Have questions about how DUPIXENT works?

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Overview of AD

Find out more about how AD has a continuous inflammation cycle.

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Inflammatory pathways

What are the main inflammatory pathways involved in the disease? Find out about the pathway involved in AD.

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AD, atopic dermatitis; IL, interleukin; Th, T-helper cells.

References

  1. DUPIXENT Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/8553/smpc. Date accessed: July 2021.
  2. Leung DYM, et al. J Clin Invest. 2004;113(5):651–657.
  3. Suárez-Fariñas M, et al. J Allergy Clin Immunol. 2011;127(4):954–964.
  4. Gittler JK, et al. J Allergy Clin Immunol. 2012;130(6):1344–1354.
  5. Gandhi NA, et al. Nat Rev Drug Discov. 2016;15:35–50.
  6. Artis D & Spits H. Nature. 2015;517:293–301.
  7. Biedermann T, et al. Front Immunol. 2015;6:353..