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  3. Atopic Dermatitis

Atopic dermatitis (AD) is a chronic disease driven by persistent underlying inflammation even in nonlesional or normal looking skin2–4

  • An imbalanced immune system, together with epidermal abnormalities, drive Type 2 inflammation2–4
  • IL-4 and IL-13 are key Th2 cytokines involved in AD2–4
  • These cytokines modulate the immune response, drive persistent inflammation and contribute to worsening barrier dysfunction2–4
UNDERLYING TYPE 2 INFLAMMATION

Learn more about the pathophysiology of AD


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Not an actual patient.

Moderate-to-severe AD has a major impact on patients’ quality of life7

It’s important to understand the effect that AD has on patients’ lives.

EXPLORE PATIENT BURDEN

Mode of action DUPIXENT

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Overview of AD

Find out more about how AD has a continuous inflammation cycle.

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Inflammatory pathways

What are the main inflammatory pathways involved in the disease? Find out about the pathway involved in AD.

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AD, atopic dermatitis; IL, interleukin; Th, T-helper cells.

References

  1. DUPIXENT Summary of Product Characteristics. September 2021.
  2. Leung DYM, et al. J Clin Invest. 2004;113(5):651–657.
  3. Suárez-Fariñas M, et al. J Allergy Clin Immunol. 2011;127(4):954–964.
  4. Gittler JK, et al. J Allergy Clin Immunol. 2012;130(6):1344–1354.
  5. Gandhi NA, et al. Nat Rev Drug Discov. 2016;15:35–50.
  6. Artis D & Spits H. Nature. 2015;517:293–301.
  7. Biedermann T, et al. Front Immunol. 2015;6:353.